Author's response to reviews Title: Evaluation of bioactive sphingolipids in 4-HPR-resistant leukemia cells Authors:

Author ' s response to reviews Title : Evaluation of bioactive sphingolipids in 4 - HPR - resistant leukemia cells

Authors: Aintzane Apraiz ([email protected]) Jolanta K Idkowiak-Baldys ([email protected]) María Dolores Boyano ([email protected]) Gorka Pérez-Yarza ([email protected]) Yusuf A Hannun ([email protected]) Aintzane Asumendi ([email protected])

Title: Evaluation of Bioactive Sphingolipids in 4-hpr-resistant Leukemia Cells

This manuscript made by Aintzane Apraiz et al. focus on the sphingolipid species profile in 4HPR-resistance CCRF-CEM cells. The whole data suggest the sphingolipid metabolism was changed compare with the resistance cells with the parent cell, and these observations suggest a alternative sphingolipid-modulating antitumoral strategies are suitable for 4HPR-resistant and sensitive leukemia cells. ...

N-(4-Hydroxyphenyl)retinamide increases dihydroceramide and synergizes with dimethylsphingosine to enhance cancer cell killing.

Fenretinide [N-(4-hydroxyphenyl)retinamide (4-HPR)] is cytotoxic in many cancer cell types. Studies have shown that elevation of ceramide species plays a role in 4-HPR cytotoxicity. To determine 4-HPR activity in a multidrug-resistant cancer cell line as well as to study ceramide metabolism, MCF-7/AdrR cells (redesignated NCI/ADR-RES) were treated with 4-HPR and sphingolipids were analyzed. TLC...

Author's response to reviews Title: A Systematic Comparison and Evaluation of High Density Exon Arrays and RNA-seq Technology used to Unravel the Peripheral Blood Transcriptome of Sickle Cell Disease. Authors:

Author's response to reviews Title: Bioactive oat beta-glucan reduces LDL cholesterol in Caucasians and non-Caucasians. Authors: